Most people with PNH have Type I and Type III cells, but the amount of each type of cell can vary greatly.ĭoctors may ask you do to several types of blood tests to help them understand your case of PNH and create a treatment plan. They are missing all the proteins that protect normal cells from attack. Of the 3 groups of cells, these break apart most easily. PNH III cells, or Type III cells: These cells are extremely sensitive to the complement system.They are missing some of the CD55 and CD59 proteins that protect them from attack. PNH II cells, or Type II cells: These cells are partially sensitive to the complement system.They respond in a healthy way to the complement system. PNH I cells, or Type I cells: These cells are normal.Using flow cytometry, your doctor can usually divide your blood cells into 3 types: FLAER is a new type of flow cytometry test that is also used. PNH cells are missing some or all of two proteins on their surface. This test tells your doctor if any proteins are missing from the surface of blood cells. The gold standard for confirming the presence of PNH is a flow cytometry test. People who have PNH may have elevated reticulocyte counts because their bone marrow is making lots of new red blood cells. A reticulocyte count measures the number of young red blood cells in your blood.High levels may indicate destruction of red blood cells. A bilirubin test measures the total amount of this substance in your blood.It is important for patients with PNH to have LDH monitored regularly. ![]() High levels of LDH in the blood can mean that red blood cells are breaking apart ( hemolysis) or that there is tissue damage in the body. ![]() An LDH test looks at the level of an enzyme called lactate dehydrogenase. ![]() This test uses a number of methods to measure how many of each blood cell type are in your blood sample.
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